منابع مشابه
[Structure-based drug design].
Structure-based drug design is not only a fundamental tool in the search of new drugs but also an area of intensive scientific research. The present contribution starts with a critical analysis of the potentiality of the structure based design and then reviews its methods. Protein crystallography, NMR, homology modelling and the use of antibodies are either referenced or briefly described as th...
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Volume 1 • Issue 4 • 1000e111 J Pharmacovigilance ISSN: 2329-6887 JP, an open access journal In today’s world where life is fast-paced, public health is a big concern. With the tremendous ongoing development in the field of pharmaceutical drugs, people can find cure for a vast variety of diseases. These modern-day medicines have been proven to be more effective in treating, managing, controllin...
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This paper presents a rule-based computer aided design framework for assembling complex internal structure. It defines each voxel with its neighborhood as an intelligent agent, which make it possible to convert the structural assembly problem into an optimization problem of a multi-agent system. We use this method in the lightweight model design. Simple defeasible rules are used to build up the...
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In this article optimal design of shear walls is performed under seismic loading. For practical aims, a database of special shear walls is created. Special shear walls are used for seismic design optimization employing the charged system search algorithm as an optimizer. Constraints consist of design and performance limitations. Nonlinear behavior of the shear wall is taken into account and per...
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This paper fully discusses how to design an observer based decentralized fuzzy adaptive controller for a class of large scale multivariable non-canonical nonlinear systems with unknown functions of subsystems’ states. On-line tuning mechanisms to adjust both the parameters of the direct adaptive controller and observer that guarantee the ultimately boundedness of both the tracking error and tha...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2011
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd3539